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Glutamine supplementation prevents the decrease of mitogen response after a treadmill exercise in rats

S Moriguchi1, H Miwa, Y Kishino

  • 1Department of Nutrition, School of Medicine, University of Tokushima, Japan.

Journal of Nutritional Science and Vitaminology
|February 1, 1995
PubMed
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A glutamine-supplemented diet prevents exercise-induced immune cell dysfunction. Supplemented rats maintained lymphocyte proliferation and IL2 production after treadmill exercise, unlike controls.

Area of Science:

  • Immunology
  • Exercise Physiology
  • Nutritional Science

Background:

  • Treadmill exercise can decrease plasma glutamine (Gln) levels.
  • Reduced Gln levels are associated with decreased immune cell function.
  • The impact of Gln supplementation on exercise-induced immune changes requires further investigation.

Purpose of the Study:

  • To investigate the effect of a glutamine-supplemented diet on the mitogen response of peripheral blood lymphocytes (PBL) after treadmill exercise.
  • To determine if Gln supplementation can prevent exercise-induced decreases in immune cell proliferation and interleukin 2 (IL2) production.

Main Methods:

  • Male Fisher rats were fed either a control or Gln-supplemented diet for 3 weeks.
  • Treadmill exercise was performed at 20 m/min for 60 min.

Related Experiment Videos

  • Plasma Gln concentrations, PBL proliferation (with phytohemagglutinin [PHA] and concanavalin A [ConA]), and IL2 production were measured before and immediately after exercise.

    • Main Results:

    • Plasma Gln levels significantly decreased in control rats post-exercise but remained stable in Gln-supplemented rats.
    • PBL proliferation and IL2 production significantly decreased in control rats post-exercise.
    • Gln-supplemented rats showed maintained PBL proliferation and IL2 production, with higher mitogen response and [3H]Gln incorporation compared to controls.

    Conclusions:

    • A Gln-supplemented diet effectively prevents exercise-induced decreases in immune cell function.
    • This protective effect is attributed to enhanced immune cell response to mitogens and increased Gln uptake for fuel and nucleotide synthesis.
    • Gln supplementation is a viable strategy to support immune function during strenuous physical activity.