Comparison of different treatment methods for localized and generalized simple denture stomatitis

Area of Science:

• Dentistry
• Mycology
• Pharmacology

Background:

• Denture stomatitis is a common oral condition.
• Fungal infections, particularly Candida albicans, are often implicated.
• Effective treatment strategies are crucial for patient comfort and oral health.

Purpose of the Study:

• To compare the efficacy of fluconazole, fluconazole plus chlorhexidine, and new denture fitting for denture stomatitis.
• To evaluate treatment outcomes for both generalized and localized forms of denture stomatitis.

Main Methods:

• Subjects with denture stomatitis were divided into three groups: fluconazole, fluconazole plus chlorhexidine, and new dentures.
• Treatment duration was two weeks, with mycological analysis of palatal swabs.
• Clinical and mycological assessments were performed before, during, and after treatment.

Main Results:

• Fluconazole plus chlorhexidine showed superior improvement in palatal inflammation for generalized denture stomatitis compared to fluconazole alone or new dentures.
• New denture fitting did not reduce inflammation in generalized denture stomatitis cases.
• Prosthetic treatment with new dentures demonstrated beneficial effects in localized denture stomatitis.

Conclusions:

• Combination therapy with fluconazole and chlorhexidine is highly effective for generalized denture stomatitis.
• New dentures are a valuable treatment option for localized denture stomatitis.
• Tailoring treatment based on the type of denture stomatitis is essential for optimal outcomes.