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Related Experiment Videos

Curcumin in a model skin lotion formulation

H Suhaimi1, F B Ahmad, S E Friberg

  • 1Chemistry Department, Faculty of Science and Environmental Studies, Universiti Pertanian Malaysia, Selangor.

Journal of Pharmaceutical Sciences
|March 1, 1995
PubMed
Summary
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A lamellar liquid crystalline region in skin lotion was studied. Adding curcumin dye reduced layer spacing and increased water penetration, but effects varied with formulation composition.

Area of Science:

  • Materials Science
  • Physical Chemistry
  • Cosmetic Science

Background:

  • Liquid crystalline phases are crucial for skin lotion formulation, influencing texture and efficacy.
  • Understanding the structural behavior of these phases is key to developing advanced cosmetic products.
  • Isostearic acid and triethanolamine (TEA) mixtures form lamellar liquid crystalline structures relevant to topical formulations.

Purpose of the Study:

  • To investigate the formation and properties of a lamellar liquid crystalline region in a model skin lotion system.
  • To determine the effect of incorporating a natural dye, curcumin, on the structural parameters of the liquid crystalline phase.
  • To assess the influence of curcumin on water penetration within the layered structure.

Main Methods:

Related Experiment Videos

  • Formation of a lamellar liquid crystalline phase using isostearic acid, triethanolamine (TEA), decane, and water at 30°C.
  • Utilizing small-angle X-ray diffraction (SAXRD) to measure interlayer spacings of the liquid crystalline structure.
  • Analyzing the impact of curcumin incorporation on the observed structural changes and water uptake.

    • Main Results:

    • A lamellar liquid crystalline region was successfully identified in the model skin lotion system.
    • Incorporation of curcumin led to reduced interlayer spacings within the lamellar structure.
    • Curcumin enhanced water penetration into the layered structure, although this effect was composition-dependent.

    Conclusions:

    • The study demonstrates that curcumin can modify the structure of lamellar liquid crystalline phases in cosmetic formulations.
    • Reduced interlayer spacing and increased water penetration by curcumin suggest potential for altered formulation performance.
    • The composition of isostearic acid:TEA, decane, and water influences the efficacy of curcumin in modulating the liquid crystalline structure and water interaction.