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Related Experiment Videos

Does adenosine receptor blockade mediate caffeine-induced rotational behavior?

B E Garrett1, S G Holtzman

  • 1Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA.

The Journal of Pharmacology and Experimental Therapeutics
|July 1, 1995
PubMed
Summary
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Caffeine and theophylline cause turning behavior in rats by blocking adenosine receptors, with tolerance developing after chronic use. Dopamine D2 receptor blockade inhibits this caffeine-induced effect.

Area of Science:

  • Neuropharmacology
  • Behavioral Neuroscience

Background:

  • Caffeine antagonizes adenosine receptors, inducing contralateral turning in rats with nigrostriatal pathway lesions.
  • Adenosine A2a and dopamine D2 receptors are negatively coupled in the striatum, suggesting a role for adenosine receptor blockade in caffeine's effects.

Purpose of the Study:

  • To investigate the role of adenosine receptor blockade in caffeine-induced rotational behavior.
  • To determine if dopamine receptor antagonists affect caffeine-induced turning.
  • To assess tolerance development to caffeine-induced rotational behavior.

Main Methods:

  • Dose-response functions for caffeine and other methylxanthine adenosine antagonists, including CGS 15943, were determined.
  • Selective dopamine D1 and D2 receptor antagonists (SCH 23390 and eticlopride) were used to block caffeine-induced turning.

Related Experiment Videos

  • Tolerance was assessed in rats chronically administered caffeine.

    • Main Results:

    • Theophylline, paraxanthine, caffeine, and beta-hydroxytheophylline induced contralateral turning, with varying potencies.
    • Eticlopride (dopamine D2 antagonist) blocked caffeine-induced turning, while SCH 23390 (dopamine D1 antagonist) did not.
    • Chronic caffeine administration led to tolerance to caffeine-induced turning and cross-tolerance to theophylline-induced turning.

    Conclusions:

    • Adenosine receptor blockade is implicated in caffeine-induced rotational behavior.
    • The dopamine D2 receptor plays a role in mediating caffeine's rotational effects.
    • Tolerance develops to the rotational effects of caffeine and cross-tolerance to theophylline.