Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Dementia in the aged]

S Hirai1

  • 1Department of Neurology, Gunma University School of Medicine.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|April 1, 1995
PubMed
Summary

Vascular dementia (VD) and Alzheimer-type dementia (ATD) are leading causes of dementia. Recent studies suggest ATD incidence may be increasing relative to VD, possibly due to better cerebrovascular disease treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dopamine and DOPA cause release of iron from ferritin and lipid peroxidation of liposomes.

Neuroreport·1999
Same author

Direct interaction of the beta-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes.

Biochemical and biophysical research communications·1999
Same author

Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response element.

Biochemical and biophysical research communications·1999
Same author

Regional cerebral blood flow abnormalities in chronic solvent abusers.

Psychiatry and clinical neurosciences·1999
Same author

Unusual cranial nerve palsy caused by cavernous sinus aneurysms. Clinical and anatomical considerations reviewed.

Surgical neurology·1999
Same author

Ultrastructure and serotonin immunocytochemistry of the parietal-pineal complex in the Japanese grass lizard, Takydromus tachydromoides.

Tissue & cell·1999

Area of Science:

  • Neurology
  • Epidemiology
  • Geriatrics

Context:

  • Vascular dementia (VD) and Alzheimer-type dementia (ATD) are the most common causes of dementia in older adults, representing over 90% of cases.
  • Epidemiological trends in Japan indicate a potential shift, with ATD incidence slightly surpassing VD, contrasting with previous observations.

Purpose:

  • To analyze the changing incidence of VD and ATD.
  • To explore the underlying reasons for the observed shift in VD/ATD ratios.
  • To review current research on ATD etiology and diagnostic markers, and VD characteristics and potential for prevention/treatment.

Summary:

  • Recent epidemiological studies show a slight increase in Alzheimer-type dementia (ATD) incidence compared to Vascular dementia (VD), potentially linked to improved cerebrovascular disease management.
  • Research into ATD focuses on neurofibrillary tangles and senile plaques, with evidence suggesting heterogeneous etiologies but a common pathway involving beta-protein and tau-protein deposition.
  • Positron emission tomography studies reveal reduced cerebral metabolic ratios in the frontal lobes of VD patients, highlighting VD as a potentially preventable and treatable form of dementia.

Impact:

  • Understanding the shifting epidemiology of dementia subtypes is crucial for public health planning and resource allocation.
  • Advances in understanding ATD pathology and diagnostics may lead to earlier detection and novel therapeutic strategies.
  • Identifying VD as a potentially preventable and treatable condition emphasizes the importance of managing cerebrovascular risk factors.

Related Experiment Videos