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Influence of route of administration on progesterone metabolism
B de Lignieres1, L Dennerstein, T Backstrom
1Département d'endocrinologie et Médecine de la Reproduction, Hopital Necker, Paris, France.
Maturitas
|April 1, 1995
Abstract:
While inducing similar progesterone levels, the ratio of 5 alpha- and 5 beta-pregnanolone/progesterone plasma concentrations has been dramatically increased after oral as opposed to vaginal administration, in a cross-over study. The known psychotropic effects of 5 alpha- and 5 beta-pregnanolone lead to different indications and precautions for oral and vaginal administration of progesterone.