[Pathomorphosis of tuberculous uveitis and keratitis]

Area of Science:

• Ophthalmology
• Infectious Diseases
• Pathology

Background:

• Tuberculous uveitis and keratitis represent significant ocular manifestations of Mycobacterium tuberculosis infection.
• Understanding the pathomorphosis of these conditions is crucial for accurate diagnosis and effective management.
• Historical data from the pre-bacterial era provides a baseline for comparison with current clinical presentations.

Purpose of the Study:

• To investigate the pathomorphosis of tuberculous uveitis and keratitis.
• To compare present-day clinical presentations with historical data.
• To identify changes in the incidence, severity, and clinical characteristics of ocular tuberculosis.

Main Methods:

• Retrospective analysis of clinical data on tuberculous uveitis and keratitis.
• Comparison of current patient data with historical literature records from the pre-bacterial period.
• Classification of inflammatory responses including chronic productive, exudative, and mixed tuberculous infections.

Main Results:

• A significant decrease in the incidence and severity of tuberculous uveitis and keratitis was observed in younger age groups.
• Present-day cases exhibit a more pronounced exudative inflammatory response.
• Clinical presentations are characterized by increased symptom polymorphism and a higher frequency of recurrences.

Conclusions:

• Tuberculosis has undergone pathomorphosis, affecting the clinical presentation of ocular manifestations like uveitis and keratitis.
• The shift towards more exudative responses and increased recurrence rates necessitates updated diagnostic and therapeutic strategies.
• Continued monitoring of pathomorphological changes in ocular tuberculosis is essential for adapting clinical practice.