[State of immunobiological reactivity of experimental animals to tuberculosis and exposure to coal tar]

Among most common environmental factors microflora and xenobiotics are capable of changing immunological resistance of human and animal body. Combined action of these factors on the animals has never been studied. Guinea pig experiments showed that M. tuberculosis can significantly change immunogram of the animals exposed for a long time to coal tar. On the one hand, the effect may be negative, but on the other, in certain conditions coal tar enhanced guinea pig's resistance to M. tuberculosis.