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Related Experiment Videos

Behavioral and developmental changes associated with prenatal opiate receptor blockade

N A Shepanek1, R F Smith, L A Anderson

  • 1George Mason University, Fairfax, VA 22030-4444, USA.

Pharmacology, Biochemistry, and Behavior
|March 1, 1995
PubMed
Summary

Prenatal exposure to naloxone in rats altered offspring neurobehavioral development. Higher doses (10 mg/kg) impacted motor skills and pain sensitivity, while lower doses (1 mg/kg) affected activity levels.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pharmacology

Background:

  • Prenatal exposure to opioid antagonists like naloxone can influence neurodevelopment.
  • Understanding the long-term effects of naloxone on offspring behavior is crucial.

Purpose of the Study:

  • To investigate the impact of prenatal naloxone exposure on the neurobehavioral development of Long-Evans hooded rat offspring.
  • To determine dose-dependent effects of naloxone on body weight, pain sensitivity, and motor activity.

Main Methods:

  • Pregnant rats received naloxone (1, 5, or 10 mg/kg/day) from gestational day 7 to 20.
  • Offspring were assessed for body weight, pain sensitivity (tail flick test), and motor behavior (open field, visual discrimination, DRL tasks).
  • Control groups included uninjected and pair-fed animals.

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Main Results:

  • Prenatal naloxone altered offspring body weight, pain sensitivity, and motor behavior.
  • Increased adult body weight in females at 5 and 10 mg/kg doses.
  • 10 mg/kg naloxone altered pain sensitivity in males and reduced bar pressing rates in a visual discrimination task.
  • 1 mg/kg naloxone led to faster habituation and reduced activity in the open field.
  • 10 mg/kg naloxone reduced bar pressing rates in DRL tasks for both males and females.

Conclusions:

  • Prenatal naloxone exposure significantly impacts neurobehavioral development in rat offspring.
  • Findings suggest a potential biphasic effect: 1 mg/kg may enhance opiate function, while 10 mg/kg may decrease it.