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No influence of ACTH on maximal performance
E Soetens1, K De Meirleir, J E Hueting
1Laboratory of Experimental Psychology, University of Brussels, Belgium.
Psychopharmacology
|April 1, 1995
Summary
Adrenocorticotropic hormone (ACTH) does not enhance maximal athletic performance in professional cyclists. While ACTH increased physiological markers and reduced fatigue during submaximal exercise, it did not improve peak performance.
Area of Science:
- Sports Science
- Endocrinology
- Exercise Physiology
Background:
- The belief that adrenocorticotropic hormones (ACTH) and corticosteroids boost athletic performance is widespread in sports.
- Scientific evidence to support these performance-enhancing claims has been lacking.
Purpose of the Study:
- To scientifically investigate the effects of ACTH on maximal performance in professional cyclists.
- To differentiate between physiological, psychological, and performance outcomes.
Main Methods:
- A double-blind, placebo-controlled study involving 16 professional cyclists.
- Administration of 1 mg ACTH or placebo, followed by cycling tests at submaximal and maximal intensities.
- Continuous self-rating of fatigue levels.
Main Results:
- Adrenocorticotropic hormone (ACTH) did not improve maximal cycling performance.
- ACTH administration led to increased cortisol, glucose, and white blood cell counts.
- Self-reported fatigue was reduced only during submaximal exercise.
Conclusions:
- The study refutes the notion that ACTH enhances maximal athletic performance.
- Physiological changes and subjective fatigue reduction during submaximal exercise may contribute to the persistent belief in ACTH's ergogenic effects.
- Differentiating physiological and performance measures is crucial for understanding doping substance beliefs.