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Updated: Jul 28, 2026
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Postoperative radiation therapy in clinical stage I endometrial cancer: corpus, cervical, and lower uterine segment
1Department of Radiology, University of Iowa College of Medicine, Iowa City 52242, USA.
Purpose:
To evaluate involvement of the lower uterine segment (LUS) in adenocarcinoma of the endometrium and to identify patterns of treatment failure.
Materials And Methods:
Two hundred four patients, aged 29-92 years, with endometrial carcinoma underwent surgery. Postoperative radiation therapy was administered for adverse histologic criteria, including deep myometrial invasion, high grade, or LUS involvement.
Results:
The incidence of tumor involvement of the LUS was 19%; of the cervix, 14%; and of the corpus, 67%. Distant metastasis occurred in 3% of patients with LUS involvement and in 17% of patients with cervical involvement. The local recurrence rate was 50% among patients with LUS involvement with no other risk factors and no postoperative radiation therapy and was 3% among those who underwent radiation therapy (P = .023).
Conclusion:
Early local-regional spread may be the primary mechanism of treatment failure in tumor invasion of the LUS. Aggressive local management, including postoperative radiation therapy, may be necessary.
