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Related Experiment Videos

Suspected multiple sclerosis: MR imaging with a thin-section fast FLAIR pulse sequence

R H Hashemi1, W G Bradley, D Y Chen

  • 1Long Beach Memorial MRI Center, Long Beach Memorial Medical Center, CA 90806, USA.

Radiology
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

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Thin-section, sagittal, fast fluid-attenuated inversion-recovery (FLAIR) magnetic resonance (MR) imaging is superior for detecting early multiple sclerosis (MS) brain lesions compared to conventional spin-echo (SE) imaging.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system.
  • Early and accurate detection of MS lesions is crucial for timely treatment and management.
  • Conventional magnetic resonance imaging (MRI) techniques may have limitations in visualizing subtle early MS changes.

Purpose of the Study:

  • To compare the efficacy of thin-section, sagittal fast fluid-attenuated inversion-recovery (FLAIR) MRI with conventional axial spin-echo (SE) MRI for the early detection of brain lesions in patients with suspected MS.
  • To evaluate the diagnostic performance of fast FLAIR sequences in identifying MS plaques.

Main Methods:

  • A double-blind study was conducted involving five healthy volunteers and 25 patients with clinically suspected MS.

Related Experiment Videos

  • Brain imaging was performed using conventional 5-mm axial proton-density- and T2-weighted SE sequences and sagittal 2-mm fast FLAIR sequences.
  • Images were independently graded by radiologists as normal or showing possible/probable MS.

    • Main Results:

    • Fast FLAIR imaging was rated as better than SE in 37% of cases and equal in 63%, with SE never being superior.
    • Abnormalities consistent with MS were detected by fast FLAIR in 43% of patients whose SE images were considered normal.
    • A characteristic subependymal striated appearance, potentially indicating early inflammation or demyelination around subependymal veins, was observed in several MS cases.

    Conclusions:

    • Sagittal thin-section fast FLAIR MRI is superior to conventional axial proton-density- and T2-weighted SE pulse sequences for detecting MS plaques in the brain.
    • Fast FLAIR imaging offers improved sensitivity for identifying early and subtle MS lesions.
    • The findings support the use of fast FLAIR as a valuable tool in the early diagnosis of multiple sclerosis.