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Detrusor in ageing and obstruction

N R Holm1, T Horn, T Hald

  • 1Department of Urology, Herlev Hospital, University of Copenhagen, Denmark.

Scandinavian Journal of Urology and Nephrology
|March 1, 1995
PubMed
Summary

Detrusor fibrosis, a bladder wall change, is linked to both aging and bladder outlet obstruction. This study found similar fibrosis levels in elderly individuals with and without obstruction, questioning the role of obstruction alone in "prostatism".

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Area of Science:

  • Urology
  • Pathology
  • Gerontology

Background:

  • Detrusor fibrosis is a pathological change in the bladder wall.
  • Its cause, whether obstruction or aging, remains debated.
  • Understanding detrusor fibrosis is crucial for conditions like benign prostatic hyperplasia (BPH).

Purpose of the Study:

  • To investigate the relationship between detrusor fibrosis, bladder outlet obstruction, and aging.
  • To compare bladder wall morphology in different age and obstruction groups.
  • To clarify the contribution of obstruction versus aging to detrusor fibrosis.

Main Methods:

  • Semiquantitative analysis of bladder wall morphology.
  • Biopsies were obtained from young healthy individuals, elderly obstructed individuals, and elderly non-obstructed individuals.
  • Histological examination focused on fibrosis within and around detrusor muscle fascicles.

Main Results:

  • Fibrosis was observed in the detrusor muscle of all analyzed groups.
  • The degree of fibrosis was comparable between elderly obstructed and non-obstructed individuals.
  • Similar levels of fibrosis were found in both obstructed and aging groups.

Conclusions:

  • Both aging and bladder outlet obstruction contribute to detrusor fibrosis.
  • The findings suggest that aging plays a significant role, independent of obstruction.
  • Further research is needed to fully elucidate the etiology of "prostatism" and its relation to obstruction and aging.

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