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Related Experiment Videos

Tuberculosis in ulcerative colitis: bird in the bush

N Kumar1, A Govil, A S Puri

  • 1Department of Gastroenterology, G.B. Pant Hospital, Delhi.

Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
|October 1, 1995
PubMed
Summary

Tuberculosis (TB) is common in Indian patients with idiopathic ulcerative colitis (UC) on steroids. Early detection and anti-TB treatment improve outcomes, highlighting the need for high clinical suspicion.

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Pulmonology

Background:

  • Idiopathic ulcerative colitis (UC) is a chronic inflammatory bowel disease.
  • The co-occurrence of tuberculosis (TB) with UC, particularly in steroid-treated patients, warrants investigation.

Purpose of the Study:

  • To determine the prevalence of tuberculosis in patients diagnosed with idiopathic ulcerative colitis in India.
  • To analyze the clinical characteristics and treatment response of UC patients with co-existing tuberculosis.

Main Methods:

  • Retrospective study of 102 patients with idiopathic ulcerative colitis.
  • Analysis of patient demographics, clinical presentation, TB diagnosis (pulmonary and intestinal), and treatment outcomes.

Main Results:

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  • Seven out of 102 UC patients (6.86%) had associated tuberculosis (3 pulmonary, 4 intestinal).
  • All intestinal TB cases involved the small bowel and occurred in females.
  • Patients with co-existing TB were on steroids and responded well to anti-TB treatment.

Conclusions:

  • Tuberculosis is prevalent in Indian patients with idiopathic ulcerative colitis, especially those on steroid therapy.
  • A high degree of clinical suspicion is crucial for diagnosing TB in this patient population.
  • Prompt anti-tubercular treatment leads to favorable outcomes, including weight gain and symptom remission.