[The immunogenetic parameters in acute and chronic glomerulonephritis in children]

Our studies suggest that children with primary diffuse glomerulonephritis have some peculiarities in the presentation of certain HLA antigens, their phenotypical and haplotypical combinations relevant to the disease risk and course variants prognosis. Children whose tissue antigens refer them to high risk group in relation to glomerulonephritis require continuous monitoring of clinical, laboratory and immunological parameters. Tissue typing can detect children predisposed to developing acute and chronic glomerulonephritis, prompt optimal treatment and follow-up policy, predict trends in the disease course.