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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

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Related Experiment Video

Updated: May 11, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
10:31

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Published on: April 20, 2018

Chronic immune colitis in rabbits

A S Mee, J E McLaughlin, H J Hodgson

    Gut
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Hypersensitivity to common bacterial antigens may cause acute colitis to become chronic. In rabbits, immune complexes induced persistent inflammation, mimicking human ulcerative colitis.

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    Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

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    Related Experiment Videos

    Last Updated: May 11, 2026

    An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
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    Published on: April 20, 2018

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    Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
    07:34

    Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

    Published on: December 16, 2021

    Area of Science:

    • Gastroenterology
    • Immunology
    • Pathology

    Background:

    • Ulcerative colitis is a chronic inflammatory bowel disease with complex etiology.
    • Bacterial antigens are implicated in the pathogenesis of inflammatory bowel disease.
    • Immune complex-mediated inflammation is a potential mechanism in chronic colitis.

    Purpose of the Study:

    • To investigate the role of bacterial antigen hypersensitivity in the chronicity of colitis.
    • To establish a rabbit model of chronic immune complex colitis.
    • To elucidate mechanisms underlying the transition from acute to chronic colitis.

    Main Methods:

    • Induction of chronic colitis in rabbits via immunization with Kunin enterobacterial antigen.
    • Establishment of immune complex colitis using soluble immune complexes and rectal formalin irritation.
    • Assessment of colitis chronicity using proctoscopy and rectal biopsy over six months.

    Main Results:

    • Kunin-sensitized rabbits developed acute colitis that persisted for six months.
    • Unsensitized rabbits or those receiving saline, antigen, or antibody alone did not develop chronic colitis.
    • Histological features in rabbits mimicked human ulcerative colitis.

    Conclusions:

    • Hypersensitivity to colonic bacterial antigens may be a key factor in developing chronic colitis.
    • Immune complex formation plays a crucial role in sustaining intestinal inflammation.
    • This rabbit model offers insights into ulcerative colitis pathogenesis.