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Hepatitis from dantrolene sodium

S P Wilkinson, B Portmann, R Williams

    Gut
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Dantrolene sodium may cause liver injury, presenting as hepatitis-like illness or abnormal liver function tests. Liver biopsies showed acute hepatitis and cholangitis-like changes, resolving after drug withdrawal.

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    Area of Science:

    • Hepatology
    • Clinical Pharmacology
    • Toxicology

    Background:

    • Dantrolene sodium is a muscle relaxant used for malignant hyperthermia and spasticity.
    • Adverse drug reactions, including hepatotoxicity, are a concern with dantrolene sodium treatment.

    Observation:

    • This study describes four patients experiencing potential adverse reactions to dantrolene sodium.
    • Clinical presentations ranged from hepatitis-like illness to asymptomatic abnormal liver function tests.

    Findings:

    • Liver biopsies revealed acute hepatitis and portal tract changes resembling ascending cholangitis in all patients.
    • Histological severity did not correlate with clinical presentation.
    • Liver function normalized upon discontinuation of dantrolene sodium.

    Implications:

    • Dantrolene sodium can induce a spectrum of liver injury.
    • Close monitoring of liver function is recommended during dantrolene sodium therapy.
    • Histopathological findings suggest a potential cholestatic component in dantrolene-induced liver injury.