Seizure after isolated fluoxetine overdose

Previous case reports of seizures following fluoxetine overdose have not adequately ruled out ingestion of other substances and have lacked documentation of increased serum drug levels. We present a case of seizure following fluoxetine overdose in a previously well patient with a clear history of sole ingestion. We ruled out the presence of other substances with comprehensive drug screening and documented increased serum levels of fluoxetine and its active metabolite.