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Topical ciprofloxacin for otorrhea after tympanostomy tube placement

R W Force1, M C Hart, S A Plummer

  • 1College of Pharmacy, Ohio State University, Wexner Institute for Pediatric Research, USA.

Archives of Otolaryngology--Head & Neck Surgery
|August 1, 1995
PubMed

Insights

Topical ciprofloxacin effectively treated ear infections in children with persistent otorrhea. This study found the antibiotic safe and effective, with no systemic absorption or adverse effects observed in pediatric patients.

Area of Science:

  • Pediatric Otolaryngology
  • Infectious Diseases
  • Pharmacokinetics

Background:

  • Otorrhea is a common complication following tympanostomy tube placement in children.
  • Persistent otorrhea can lead to treatment challenges and potential hearing impairment.
  • Pseudomonas aeruginosa is a frequent causative agent in pediatric otorrhea.

Purpose of the Study:

  • To assess the efficacy of topical ciprofloxacin in treating pediatric otorrhea.
  • To evaluate the systemic absorption of ototopically administered ciprofloxacin.
  • To determine the safety profile of topical ciprofloxacin in children.

Main Methods:

  • A nonrandomized, open-label pilot trial was conducted in a pediatric otolaryngology clinic.
  • Patients aged 3-8 years with persistent otorrhea and Pseudomonas aeruginosa infection received topical ciprofloxacin for 14 days.
  • Pharmacokinetic analysis was performed to measure systemic absorption, alongside audiometry and clinical evaluations for efficacy and safety.

Main Results:

  • Topical ciprofloxacin demonstrated high efficacy, with 10 of 11 infected ears showing improvement or cure by day 7, and complete cure by days 14 and 44.
  • No systemic absorption of ciprofloxacin was detected in any of the pediatric participants.
  • No adverse effects were reported, and bone conduction audiometry results normalized in all children by day 14.

Conclusions:

  • Topical ciprofloxacin is a safe and effective treatment for pediatric otorrhea unresponsive to other therapies.
  • The drug exhibits minimal to no systemic absorption when administered topically in children.
  • This treatment offers a promising alternative for managing challenging cases of otorrhea in pediatric patients.
Abstract

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