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Related Experiment Videos

Oxygen tension under a contact lens

K A Polse, M Decker

    Investigative Ophthalmology & Visual Science
    |February 1, 1979
    PubMed
    Summary

    Contact lens center thickness affects oxygen levels reaching the cornea. Insufficient oxygen under the lens causes corneal swelling, necessitating specific oxygen transmissibility for healthy eyes.

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    Area of Science:

    • Ophthalmology
    • Corneal Physiology
    • Contact Lens Technology

    Background:

    • Corneal oxygen levels are crucial for maintaining corneal health.
    • Contact lenses can alter the oxygen supply to the cornea.
    • Previous studies have linked corneal thickness changes to oxygen deprivation.

    Purpose of the Study:

    • To determine the relationship between contact lens center thickness and corneal oxygen tension.
    • To establish critical oxygen tension and flux thresholds that prevent corneal swelling.
    • To define the minimum oxygen transmissibility required for contact lenses under open and closed eye conditions.

    Main Methods:

    • Human subjects wore gel contact lenses with varying center thicknesses.
    • Corneal thickness changes were measured to assess oxygen deprivation.
    • Data were combined with previous studies on corneal response to low oxygen tensions.

    Main Results:

    • Oxygen tension under most contact lenses ranges from 0 to 25 mm Hg, with a corresponding oxygen flux of 0 to 6 microliter cm2 hr.
    • A critical oxygen tension of 10 mm Hg and flux of 2 microliter cm2 hr were identified, below which corneal swelling occurs.
    • Minimum oxygen transmissibility values of 5 X 10(-9) and 15 X 10(-9) (cm X ml O2)/(sec X ml X mm Hg) are required for open and closed eyes, respectively.

    Conclusions:

    • Contact lens design, specifically center thickness, directly impacts corneal oxygenation.
    • Maintaining adequate oxygen supply is essential to prevent contact lens-induced corneal edema.
    • Specific oxygen transmissibility standards are necessary for safe and effective contact lens wear in both open and closed eye states.

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