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Related Experiment Videos

Early sensitization to airborne allergens

Z Szépfalusi1, W D Huber, C Ebner

  • 1Department of Pediatrics, University of Vienna, Austria.

International Archives of Allergy and Immunology
|August 1, 1995
PubMed
Summary
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An infant with failure to thrive showed celiac disease markers and immune responses to pollen and nuts. Early food introduction may have triggered cross-reactivity, suggesting prenatal sensitization.

Area of Science:

  • Pediatrics
  • Immunology
  • Gastroenterology

Background:

  • Celiac disease diagnosis in infants requires careful evaluation of symptoms like failure to thrive.
  • Early infant feeding practices can influence immune system development and allergy risk.

Observation:

  • A 7-month-old infant presented with failure to thrive, elevated antigliadin antibodies (IgA and IgG), and subtotal villous atrophy, suggestive of celiac disease.
  • Peripheral blood mononuclear cells exhibited proliferation in response to birch pollen, rye pollen, and hazelnut extract.
  • The infant had been exposed to foods associated with birch pollen allergy (carrot, apple, potato) from 6 weeks of age.

Findings:

  • Specific IgA, IgG, and IgM antibodies to birch pollen, profilin, rye pollen, and hazelnut antigens were detected in the infant's serum.

Related Experiment Videos

  • Cellular proliferation indicated an immune response to environmental allergens and food antigens.
  • The findings suggest potential in utero sensitization or T cell cross-reactivity due to early exposure to related food antigens.

    • Implications:

    • This case highlights the possibility of early-onset allergic sensitization and cross-reactivity in infants.
    • Understanding the interplay between early diet, environmental allergens, and immune responses is crucial for diagnosing and managing pediatric allergies and celiac disease.