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NO-donors in cardiology

H Vapaatalo1

  • 1Department of Pharmacology and Toxicology, University of Helsinki, Finland.

Polish Journal of Pharmacology
|November 1, 1994
PubMed
Summary

Nitrates, used for over a century to treat angina, are now understood to release nitric oxide (NO), aiding vasodilation. This review explores their current use in cardiology and future potential for various conditions.

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Area of Science:

  • Pharmacology
  • Cardiology
  • Biochemistry

Background:

  • Nitrates have a long history in treating cardiac diseases, initially for angina pectoris.
  • Their clinical applications have expanded due to new insights into their mechanisms and effects.

Purpose of the Study:

  • To review the current status of nitrates in cardiology.
  • To discuss the pharmacokinetics, pharmacodynamics, and cellular mechanisms of nitrates.
  • To predict future applications of nitrates and other nitric oxide donors.

Main Methods:

  • Literature review of existing studies on nitrates.
  • Analysis of pharmacokinetic and pharmacodynamic data.
  • Discussion of the cellular mechanism involving nitric oxide (NO) release.

Main Results:

  • Nitrates release nitric oxide (NO), a vasodilator, which is physiologically produced by vascular endothelium (EDRF).
  • Nitrates can substitute for endogenous NO in conditions with reduced or altered NO production.
  • New NO-donor agents are emerging for cardiovascular and other smooth muscle-related disorders.

Conclusions:

  • Nitrates remain crucial in cardiovascular medicine, with evolving understanding of their action.
  • Future research will likely focus on novel NO-donors for a broader range of therapeutic applications.
  • The role of NO in physiology and pathology continues to be a key area for therapeutic innovation.

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