Chaos in intracellular Ca2+ oscillations in a new model for non-excitable cells
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Updated: Sep 15, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
Abstract:
A new model for intracellular Ca2+ oscillations is presented. The new model reinterprets two previous models, the ICC and CICR mechanisms, and incorporates the bell-shaped dependence of Ca2+ release on cytosolic [Ca2+]. Complex oscillations and chaos are found with this new model, confirming experimental observations of complex oscillations. A rich bifurcation sequence is found for the model as the stimulation due to agonist (R) is varied, including a period doubling route to chaos and a period-adding sequence of mixed-mode states.
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