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Related Experiment Videos

Hypoglycemic effects of three plants from eastern Himalayan belt

M Mosihuzzaman1, N Nahar, L Ali

  • 1Department of Chemistry, University of Dhaka, Bangladesh.

Diabetes Research (Edinburgh, Scotland)
|January 1, 1994
PubMed
Summary

Three Eastern Himalayan plants were studied for their effects on blood glucose. Costus speciosus and Nephrolepis tuberosa showed hypoglycemic effects in rat models, suggesting potential as oral hypoglycemic agents.

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Area of Science:

  • Ethnobotany
  • Pharmacology
  • Endocrinology

Background:

  • Traditional healers in the Eastern Himalayas utilize Costus speciosus, Nephrolepis tuberosa, and Stephania hernandifolia.
  • These plants are used for various ailments, with potential applications in metabolic disorders.

Purpose of the Study:

  • To investigate the effects of freeze-dried juices from C. speciosus, N. tuberosa, and S. hernandifolia on serum glucose levels.
  • To evaluate these effects in nondiabetic and diabetic (NIDDM and IDDM) rat models at different prandial states.

Main Methods:

  • Administration of freeze-dried plant juices to rat models (nondiabetic, NIDDM, IDDM).
  • Assessment of serum glucose levels under fasting and postprandial conditions (simultaneous or 30 min pre-glucose load).
  • Statistical analysis of glucose level changes (p-values reported).

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Main Results:

  • Costus speciosus and Nephrolepis tuberosa exhibited significant hypoglycemic effects in nondiabetic and NIDDM models when administered before glucose load.
  • Stephania hernandifolia increased serum glucose in nondiabetic rats but showed hypoglycemic effects in IDDM models.
  • Costus speciosus demonstrated a hypoglycemic effect in IDDM models when administered with glucose.

Conclusions:

  • Costus speciosus and Nephrolepis tuberosa show promise as sources of oral hypoglycemic agents.
  • Stephania hernandifolia exhibits differential effects on glucose levels depending on the model, warranting further investigation.
  • These findings support the ethnobotanical use of these plants and their potential in diabetes management.