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Discriminant function using red cell indices to distinguish between HbC and HbE traits

R F Hinchliffe1, S P Ellis, J S Lilleyman

  • 1Section of Paediatric Haematology, University of Sheffield Department of Paediatrics, Children's Hospital, Western Bank, UK.

Clinical and Laboratory Haematology
|March 1, 1995
PubMed

Values for MCV, MCH, MCHC and red cell distribution width (RDW) derived from subjects with HbC and HbE traits using a Technicon H*1 automated blood count analyser were compared. Significantly higher MCH, MCHC and RDW values were found in those with HbC trait. By use of a simple discriminant function (MCHC2 x RDW/1000), 19/20 subjects with HbC trait gave a value > or = 16.3, and 20/21 subjects with HbE trait gave a value < or = 16.2. The function described may be of value as an adjunct to electrophoresis in intralaboratory quality control.

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