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Related Experiment Videos

Metabolic parameter, bleeding, and weight changes in U.S. women using progestin only contraceptives

R Mainwaring1, H A Hales, K Stevenson

  • 1Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City 84132, USA.

Contraception
|March 1, 1995
PubMed
Summary

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Progestin-only contraceptives like implants and injections showed no significant metabolic or weight changes in women over one year. Bleeding patterns varied, with depo-medroxyprogesterone acetate leading to amenorrhea.

Area of Science:

  • Reproductive Health
  • Endocrinology
  • Metabolic Studies

Background:

  • Progestin-only contraceptives are widely used for family planning.
  • Understanding their long-term effects on metabolic health and bleeding is crucial for informed choices.

Purpose of the Study:

  • To evaluate the impact of different progestin-only contraceptives on metabolic parameters, bleeding patterns, and weight changes.
  • To compare levonorgestrel implants, depo-medroxyprogesterone acetate, and oral norethindrone over one year of use.

Main Methods:

  • Seventy-one women self-selected progestin-only contraceptives.
  • Metabolic parameters (lipids, lipoproteins, etc.) were measured pre- and post-contraception in a subset.
  • Monthly bleeding/spotting and body weight were monitored for one year.
Keywords:
AmericasBiologyBleedingBody Weight--changesClinical ResearchContraceptionContraceptive AgentsContraceptive Agents, FemaleContraceptive Agents, ProgestinContraceptive ImplantsContraceptive MethodsDepo-proveraDeveloped CountriesDiseasesFamily PlanningLevonorgestrelMedroxyprogesterone AcetateMenstruation DisordersMetabolic EffectsNorethindroneNorth AmericaNorthern AmericaOral ContraceptivesPhysiologyProgestins, Low-doseResearch ReportSigns And SymptomsUnited StatesUtah

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Main Results:

  • No statistically significant changes in metabolic parameters or weight were observed with levonorgestrel implants or depo-medroxyprogesterone acetate.
  • Continued bleeding was more common with levonorgestrel implants and oral norethindrone compared to depo-medroxyprogesterone acetate.
  • Depo-medroxyprogesterone acetate showed the highest incidence of amenorrhea.

Conclusions:

  • Progestin-only contraceptives, specifically levonorgestrel implants and depo-medroxyprogesterone acetate, do not significantly alter metabolic parameters or cause weight gain within the first year.
  • Bleeding pattern variations exist among different progestin-only methods, with depo-medroxyprogesterone acetate associated with amenorrhea.