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Updated: Aug 6, 2026
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Manipulating the Murine Lacrimal Gland
Published on: November 18, 2014
Lacrimal gland lymphoma: a cytomorphologic and immunophenotypic study
P B Jeffrey1, D Cartwright, S K Atwater
1Department of Anatomic Pathology, University of California, San Francisco, USA.
Diagnostic Cytopathology
|May 1, 1995
Summary
Fine-needle aspiration cytology can identify malignant lymphoma in the lacrimal gland. This method provides ideal tissue for analysis, aiding in the diagnosis of these lymphoid lesions.
Area of Science:
- Ophthalmology
- Hematology
- Cytopathology
Background:
- Lacrimal gland lymphoma cytomorphology is not well-defined.
- Accurate diagnosis is crucial for appropriate treatment.
Purpose of the Study:
- To describe the cytomorphology of lacrimal gland lymphoma.
- To evaluate fine-needle aspiration (FNA) as a diagnostic tool.
Main Methods:
- Analysis of six cases of histologically confirmed lacrimal gland lymphoma.
- Utilized fine-needle aspiration cytology, immunophenotype analysis, and immunoglobulin gene rearrangement studies.
Main Results:
- FNA cytology revealed atypical lymphoid cell populations.
- Immunophenotype analysis confirmed B-cell origin with monotypic surface immunoglobulin.
- Immunoglobulin gene rearrangement was detected in three cases.
Conclusions:
- Fine-needle aspiration is a valuable adjunct for diagnosing malignant lymphoid lesions of the lacrimal gland.
- FNA provides suitable material for cytologic and immunophenotypic evaluation, potentially reducing the need for surgical biopsy.
- Further research is needed to differentiate benign from malignant lymphoid proliferations using FNA.
