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Related Experiment Videos

Pulmonary hypertension and dexfenfluramine

P Cacoub, R Dorent, P Nataf

    European Journal of Clinical Pharmacology
    |January 1, 1995
    PubMed
    Summary

    Appetite suppressants like dexfenfluramine are linked to dangerous pulmonary hypertension. This report details two lethal cases, highlighting the risks of these weight-loss drugs.

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    Area of Science:

    • Cardiology
    • Pharmacology
    • Pulmonology

    Background:

    • Appetite suppressants, including aminorex and fenfluramine, have historical associations with pulmonary hypertension.
    • Primary pulmonary hypertension outbreaks were previously linked to aminorex treatment in Europe.

    Observation:

    • The use of dexfenfluramine, a newer anorectic agent, has significantly increased in developed nations.
    • Two new cases of fatal pulmonary hypertension were observed in patients using dexfenfluramine.

    Findings:

    • Dexfenfluramine use is associated with severe, lethal pulmonary hypertension.
    • The drug's mechanism may involve vascular remodeling or direct toxicity contributing to pulmonary arterial pressure.

    Implications:

    • Clinicians should exercise caution when prescribing dexfenfluramine due to its association with severe pulmonary hypertension.
    • Further research is warranted to elucidate the specific mechanisms linking dexfenfluramine to pulmonary hypertension and to identify at-risk populations.

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