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Characterization of recombinant tetanus toxin derivatives suitable for vaccine development
D Figueiredo1, C Turcotte, G Frankel
1Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom.
Infection and Immunity
|August 1, 1995
Abstract:
Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.