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Updated: Aug 2, 2026

A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
Scalpel excision of primary cutaneous malignant melanomas without metastasis
Abstract:
Views and opinions about surgical treatment of primary malignant melanomas that are without local spread or metastasis are presented. An attempt is made to determine the limitations of office-based dermatologists in the treatment of malignant melanomas of this stage. Using accepted criteria for clinical recognition of malignant melanomas early, it is suggested that surgical excisions of small malignant melanomas that are judged to be complete obviate preliminary biopsies and furnish surgical specimens that can be read histopathologically for confirmation of clinical diagnosis and adequacy of excision.
Insights
Early surgical excision of small malignant melanomas, when complete, can bypass preliminary biopsies. This approach provides specimens for histopathology, confirming diagnosis and excision adequacy for office-based dermatologists.
Area of Science:
- Dermatology
- Surgical Oncology
Background:
- Malignant melanoma requires timely and accurate diagnosis and treatment.
- Office-based dermatologists face challenges in managing early-stage melanoma.
Purpose of the Study:
- To evaluate the feasibility and limitations of office-based dermatologists in surgically treating early-stage primary malignant melanomas.
- To propose an optimized surgical approach for small, localized melanomas.
Main Methods:
- Review of accepted criteria for early clinical recognition of malignant melanomas.
- Discussion of surgical excision techniques for small melanomas.
- Analysis of histopathological evaluation of excised specimens.
Main Results:
- Complete surgical excision of small malignant melanomas can be performed effectively in an office setting.
- Preliminary biopsies may be obviated when excisions are deemed complete.
- Histopathological examination confirms diagnosis and assesses excision margins.
Conclusions:
- Office-based dermatologists can effectively manage early-stage malignant melanomas through complete surgical excision.
- This approach streamlines diagnosis and treatment, ensuring adequate margin assessment.
- Optimized surgical strategies enhance patient care for localized melanoma.
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