Related Experiment Videos
The isolation and structural elucidation of three new neolignans, piperulins [corrected] A, B, and C, as platelet
1Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.
Journal of Natural Products
|April 1, 1995
Abstract:
Three new neolignans, piperulins [corrected] A [1], B [2], and C [3], were isolated from Piper puberulum. Their structures and relative stereochemistries were determined from spectral data and the X-ray crystallographic analysis of 1. Compounds 1 and 3 inhibit specific platelet activating factor receptor binding with IC50 values of 7.3 and 5.7 microM, respectively.