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Four cyclopeptide alkaloids from Discaria longispina

E C Machado1, A Alvarez Filho, A F Morel

  • 1Departamento de Quimica, Universidade Federal de Santa Maria, RS, Brazil.

Journal of Natural Products
|April 1, 1995
PubMed
Summary

Researchers isolated four cyclopeptide alkaloids, including a novel 14-membered alkaloid named discarine-X, from D. longispina. The structure of this new compound was determined using spectroscopic and chemical methods.

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Area of Science:

  • Natural Product Chemistry
  • Pharmacognosy
  • Medicinal Chemistry

Background:

  • D. longispina is a plant species known to produce bioactive compounds.
  • Cyclopeptide alkaloids represent a class of natural products with diverse biological activities.
  • Previous research has identified various alkaloids from D. longispina, but novel structures continue to be discovered.

Purpose of the Study:

  • To isolate and characterize cyclopeptide alkaloids from D. longispina.
  • To elucidate the structure of a newly discovered 14-membered cyclopeptide alkaloid.
  • To contribute to the understanding of the chemical diversity of alkaloids in D. longispina.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation employing spectroscopic methods (e.g., NMR, Mass Spectrometry).

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  • Chemical degradation studies to confirm structural features.

    • Main Results:

    • Four cyclopeptide alkaloids were successfully isolated: adoutine-Y, discarine-B, discarine-E, and discarine-X.
    • Discarine-X was identified as a new 14-membered cyclopeptide alkaloid.
    • The structure of discarine-X was fully elucidated through comprehensive spectroscopic and chemical analyses.

    Conclusions:

    • The study successfully identified known and a novel cyclopeptide alkaloid from D. longispina.
    • The characterization of discarine-X expands the known chemical structures within this alkaloid class.
    • These findings enhance the knowledge of D. longispina's phytochemical profile and potential for novel drug discovery.