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Related Experiment Videos

Castleman's disease presenting as a pediatric surgical problem

V J Shroff1, B F Gilchrist, F G DeLuca

  • 1Department of Surgery, Brown University School of Medicine, Rhode Island Hospital, Providence 02903, USA.

Journal of Pediatric Surgery
|May 1, 1995
PubMed
Summary

Castleman disease, a rare pediatric lymph node disorder, can cause anemia and fever. Surgical removal of the affected lymph node mass successfully resolved the symptoms in a 9-year-old girl.

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Area of Science:

  • Pediatric Oncology
  • Hematology
  • Surgical Pathology

Background:

  • Castleman disease is a rare lymphoproliferative disorder affecting lymph nodes.
  • Plasma cell Castleman disease is a subtype with distinct clinical and pathological features.
  • Pediatric cases of Castleman disease are exceptionally infrequent, posing diagnostic challenges.

Observation:

  • A 9-year-old female presented with a 2.5-year history of anemia, fever, and failure to thrive.
  • Physical examination revealed a palpable mass in the right lower quadrant.
  • Clinical presentation suggested Castleman disease, plasma cell type.

Findings:

  • Histopathological examination confirmed the mass as a giant hyperplastic lymph node consistent with Castleman disease.
  • Complete surgical excision of the affected lymph node was performed.

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  • Post-operative recovery was uneventful, with complete resolution of presenting symptoms.

    • Implications:

    • This case highlights Castleman disease as a treatable cause of anemia and mass in children.
    • Complete surgical excision is curative for localized Castleman disease.
    • Increased awareness of this rare condition is crucial for timely diagnosis and management in pediatric patients.