Related Experiment Video

Updated: Sep 19, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

Antibacterial activity of a substance produced by the fungus Pycnoporus sanguineus (Fr.) Murr

A Smânia1, F D Monache, E F Smânia

  • 1Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Catarina, Florianópolis, Brazil.

Journal of Ethnopharmacology
|March 1, 1995
PubMed

Insights

A Pycnoporus sanguineus fungal extract shows antimicrobial activity, particularly against Gram-positive bacteria like Staphylococcus aureus. This natural compound offers potential for new antibacterial therapies.

Area of Science:

  • Mycology
  • Microbiology
  • Natural Product Chemistry

Background:

  • The rise of antibiotic resistance necessitates the discovery of novel antimicrobial compounds.
  • Fungi are a rich source of bioactive molecules with potential therapeutic applications.

Purpose of the Study:

  • To investigate the antimicrobial properties of a fraction derived from Pycnoporus sanguineus culture fluids.
  • To identify the spectrum of activity against various bacterial pathogens.

Main Methods:

  • Extraction and purification of a bioactive fraction from Pycnoporus sanguineus.
  • In vitro susceptibility testing against a panel of Gram-positive and Gram-negative bacteria.

Main Results:

  • The fungal fraction exhibited significant biological activity against tested bacterial strains.
  • The compound demonstrated markedly higher efficacy against Gram-positive cocci (e.g., Staphylococcus aureus) compared to Gram-negative bacilli (e.g., Escherichia coli).

Conclusions:

  • Pycnoporus sanguineus produces a compound with notable antibacterial activity.
  • This natural product shows selective potency against Gram-positive bacteria, suggesting potential for targeted antimicrobial development.

More Related Videos

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products06:47

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

Published on: December 5, 2020

Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks09:18

Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks

Published on: December 2, 2022

Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
Production of Antibiotics01:27

Production of Antibiotics

Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...