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An avian model for the reversal of 6-hydroxydopamine induced rotating behaviour by neural grafting
J Yanai1, W F Silverman, D Shamir
1Melvin A. and Eleanor Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Embryology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Abstract:
A new animal model of parkinsonism was established in 'Black Silkie' chickens by means of unilateral injections of 6-hydroxy-dopamine into the substantia nigra. Apomorphine produced a strong contralateral turning pattern in the lesioned chickens, amphetamine had no effect. 6-OHDA treated animals received embryonic transplants of substantia nigra cell suspensions which caused them to cease rotating (P < 0.01). This finding allows us to add an avian model, which offers unique methodological advantages, for reversal of 6-OHDA-induced rotating behavior by transplantation.