Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lamotrigine

A H Burstein1

  • 1Division of Neuropharmacology, Dent Neurologic Institute, Millard Fillmore Hospital, Buffalo, NY 14209, USA.

Pharmacotherapy
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

Lamotrigine is a novel antiepileptic drug effective for refractory partial seizures in adults. It works by affecting sodium channels and glutamate release, offering an alternative to existing treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commentary: Future of Alzheimer's Disease Treatment: Combination Therapy and Precision Medicine.

The journal of prevention of Alzheimer's disease·2023
Same author

Development of Azeliragon, an Oral Small Molecule Antagonist of the Receptor for Advanced Glycation Endproducts, for the Potential Slowing of Loss of Cognition in Mild Alzheimer's Disease.

The journal of prevention of Alzheimer's disease·2018
Same author

Lack of a pharmacokinetic interaction between a new smoking cessation therapy, varenicline, and digoxin in adult smokers.

European journal of clinical pharmacology·2008
Same author

Human abuse liability of the smoking cessation drug varenicline in smokers and nonsmokers.

Clinical pharmacology and therapeutics·2008
Same author

Effect of human renal cationic transporter inhibition on the pharmacokinetics of varenicline, a new therapy for smoking cessation: an in vitro-in vivo study.

Clinical pharmacology and therapeutics·2007
Same author

Pilot trial of 1-octanol in essential tremor.

Neurology·2004
Same journal

The Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single Oral Dose of Zongertinib in Healthy Male Volunteers.

Pharmacotherapy·2026
Same journal

Menopausal Hormone Therapy: A Narrative Review of Contemporary Evidence.

Pharmacotherapy·2026
Same journal

Getting It Right the Second Time: How Can we Optimize First-Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

Pharmacotherapy·2026
Same journal

Buprenorphine Initiation During Extracorporeal Membrane Oxygenation Decreases Sedative and Opioid Exposure: A Retrospective Matched Case-Control Study.

Pharmacotherapy·2026
Same journal

Voriconazole Dosing and Therapeutic Drug Monitoring in Patients Before and After Liver Transplantation.

Pharmacotherapy·2026
Same journal

Quantifying the Serum Magnesium Response and Predictors of Response Following Intravenous Magnesium Replacement in Critically Ill Patients.

Pharmacotherapy·2026
See all related articles

Area of Science:

  • Pharmacology
  • Neuroscience
  • Clinical Medicine

Background:

  • Epilepsy is a neurological disorder characterized by recurrent seizures.
  • Existing antiepileptic drugs have limitations in efficacy and side effect profiles.
  • Novel therapeutic agents are needed to improve seizure control and patient outcomes.

Purpose of the Study:

  • To evaluate the efficacy and safety of lamotrigine as an antiepileptic treatment.
  • To explore the potential of lamotrigine in managing partial and generalized seizures.
  • To understand the pharmacokinetic profile and elimination pathways of lamotrigine.

Main Methods:

  • Clinical trials involving adult patients with refractory partial seizures.
  • Pharmacokinetic studies assessing oral absorption and hepatic glucuronidation.

Related Experiment Videos

  • Analysis of reported side effects and adverse events.

    • Main Results:

    • Lamotrigine demonstrated efficacy as add-on therapy for refractory partial seizures.
    • Preliminary data suggest potential utility in generalized seizures and monotherapy.
    • Commonly reported side effects include rash, nausea, vomiting, and visual disturbances.

    Conclusions:

    • Lamotrigine is a promising antiepileptic agent with a favorable efficacy profile.
    • Further controlled trials are necessary to establish its role in monotherapy.
    • Lamotrigine represents an attractive alternative to current antiepileptic medications.