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Related Experiment Videos

The asialoglycoprotein receptor: relationships between structure, function, and expression

R J Stockert1

  • 1Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.

Physiological Reviews
|July 1, 1995
PubMed
Summary
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The asialoglycoprotein receptor is key to cellular uptake and intracellular transport. Its structure and function impact gene expression and viral interactions, offering insights into cell differentiation and therapeutic targeting.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Receptor-mediated endocytosis is a critical cellular process for internalizing macromolecules.
  • The asialoglycoprotein receptor (ASGPR) serves as a model for understanding constitutive endocytosis via coated pits.
  • ASGPR's role extends beyond endocytosis, influencing cell-cell interactions and viral uptake.

Purpose of the Study:

  • To review diverse findings on the asialoglycoprotein receptor.
  • To relate receptor structure and function to its expression.
  • To explore ASGPR's implications in hepatocellular differentiation and therapeutic applications.

Main Methods:

  • Review of existing literature on asialoglycoprotein receptor function.
  • Analysis of receptor structure and its relationship to endocytosis.

Related Experiment Videos

  • Examination of ASGPR's role in cellular signaling and gene regulation.

    • Main Results:

    • ASGPR mediates ligand transport through distinct intracellular compartments.
    • ASGPR's structure-function relationship is crucial for its role in endocytosis.
    • ASGPR expression is linked to hepatocellular differentiation and translational regulation.

    Conclusions:

    • The asialoglycoprotein receptor is a multifaceted protein with implications for cellular transport, signaling, and disease.
    • Understanding ASGPR's complex regulation provides insights into hepatocellular function.
    • ASGPR research supports targeted drug delivery and gene therapy strategies.