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The effects of phenylephrine 2.5% versus phenylephrine 10% on pupillary dilation in patients with diabetes
J S Weiss1, J N Weiss, D S Greenfield
1Kresge Eye Institute, Detroit, Michigan 48201, USA.
Purpose:
A prospective, double-blind study was conducted to compare the clinical efficacy of a combination of 1% tropicamide and 2.5% phenylephrine and a combination of 1% tropicamide and 10% phenylephrine for pupillary dilation in patients with diabetes.
Methods:
Either 2.5% phenylephrine in one eye and 10% phenylephrine in the other eye, 2.5% phenylephrine in both eyes, or 10% phenylephrine in both eyes was administered to 127 consecutive patients with diabetes. All patients received 1% tropicamide in both eyes.
Results:
There was no statistically significant difference in the amount of pupillary dilation between the three groups.
Conclusion:
As 2.5% phenylephrine may produce a lower incidence of side effects than the 10% concentration, we advise the use of the lower concentration, particularly among patients with diabetes, who already exhibit a higher prevalence of vascular disease and autonomic dysfunction.