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Related Experiment Videos

H-reflex modulation during gait in multiple sclerosis patients with spasticity

T Sinkjaer1, E Toft, H J Hansen

  • 1Department of Informatics and Image Analysis, Aalborg University, Hospital for Treatment of Multiple Sclerosis, Ry, Denmark.

Acta Neurologica Scandinavica
|April 1, 1995
PubMed
Summary

Spastic multiple sclerosis patients show impaired Hoffmann (H-) reflex modulation during walking. This reflex is solely dependent on muscle excitation levels, unlike in healthy individuals.

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Area of Science:

  • Neuroscience
  • Motor Control
  • Clinical Neurology

Background:

  • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • Spasticity is a common symptom in MS, impacting motor function and gait.
  • The Hoffmann (H-) reflex is a valuable tool for assessing spinal cord excitability and motor pathways.

Purpose of the Study:

  • To quantify Hoffmann (H-) reflex modulation in the soleus muscle during walking in spastic MS patients.
  • To determine the influence of soleus muscle excitation level on H-reflex modulation.
  • To compare H-reflex modulation patterns between spastic MS patients and healthy individuals.

Main Methods:

  • Quantified H-reflex modulation using minimum H-reflex during swing phase and modulation index.

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  • Matched stimulus strengths across subjects for accurate neurophysiological assessment.
  • Investigated H-reflex modulation during walking at varying stimulus intensities in moderate spastic MS patients.

    • Main Results:

    • H-reflex modulation is significantly impaired in moderate spastic MS patients.
    • Impaired modulation was observed with both strong and weak afferent input to the motoneuron pool.
    • In spastic MS patients, H-reflex modulation was solely related to muscle excitation levels.

    Conclusions:

    • H-reflex modulation is compromised in spastic MS, suggesting altered spinal cord processing.
    • Unlike healthy subjects, H-reflex modulation in spastic MS patients is primarily driven by muscle excitation levels.
    • Findings highlight the impact of spasticity on reflex pathways and motor control in MS.