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Glomerular function in sickle cell disease patients during crisis
A Aderibigbe1, A Arije, O O Akinkugbe
1University of Ilorin Teaching Hospital, Department of Medicine, Nigeria.
African Journal of Medicine and Medical Sciences
|June 1, 1994
Summary
Sickle cell disease (SCD) crises temporarily impair kidney function, specifically glomerular filtration. However, this kidney dysfunction in sickle cell patients during crisis is reversible.
Area of Science:
- Nephrology
- Hematology
- Internal Medicine
Background:
- Sickle cell disease (SCD) is a genetic blood disorder characterized by abnormal hemoglobin.
- Vaso-occlusive crises are a hallmark of SCD, leading to significant pain and organ damage.
- The impact of SCD crises on renal function, particularly glomerular filtration, requires further investigation.
Purpose of the Study:
- To assess the effect of sickle cell crises on glomerular function in adult SCD patients.
- To determine the reversibility of crisis-induced glomerular dysfunction.
Main Methods:
- Prospective study of 20 adult SCD patients (16 HbSS, 4 HbSC) over 8 months.
- Measurement of creatinine clearance (CCr) as an index of glomerular function.
- CCr levels were assessed at pre-crisis, during crisis, and at 2, 4 weeks, and end of study post-crisis.
Main Results:
- Mean CCr significantly decreased from 113.37 mL/min pre-crisis to 96.39 mL/min during crisis (p < 0.001).
- Glomerular function showed significant improvement by 4 weeks post-crisis, reaching 107.75 mL/min (p < 0.001).
- No significant difference in CCr was observed at the end of the study compared to pre-crisis levels.
Conclusions:
- Sickle cell crises induce potentially reversible glomerular dysfunction in SCD patients.
- Monitoring glomerular function during and after crises is crucial for managing SCD patients.
- Early detection and management may prevent long-term renal complications in SCD.