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[Chromosome microdissection: applications and prospects]
1Laboratoire Central d'Hématologie, Hôpital Saint-Louis, Paris, France.
Annales De Genetique
|January 1, 1995
Abstract:
A new microdissection and microcloning procedure of human banded chromosomes has been described. These micro-techniques allow the construction of band-specific DNA libraries, providing a large number of DNA probes for the identification of gene sequences. These technologies associated with fluorescence in situ hybridization studies are particularly efficient to analyse chromosomal regions involved in human genetic diseases including cancer.