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Synthesis of some N,N-disubstituted carbamodithioic acid esters tested for antifungal activity
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
Farmaco (Societa Chimica Italiana : 1989)
|May 1, 1995
Abstract:
The synthesis of 12 new 4-[(N,N-disubstituted thiocarbamoylthio)acetamido]antipyrines and their antifungal activity are reported. Of these compounds, only 3e, showed good antifungal activity against C. tropicalis KUEN 1021, C. krusei KUEN 1001, C. stellatoidea KUEN 1018, C. pseudotropicalis KUEN 1012, C. albicans ATCC 10231 when compared with clotrimazole and miconazole (MIC = 12.5 micrograms/ml).