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Related Experiment Videos

Root formation

H F Thomas1

  • 1Department of Pediatric Dentistry, University of Texas Health Science Center, San Antonio 78284-7888, USA.

The International Journal of Developmental Biology
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

This review details biological mechanisms in root development, comparing rodent models to human relevance. It highlights differences in odontoblast differentiation and cementum formation, emphasizing the epithelial root sheath's role.

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Area of Science:

  • Dental Biology
  • Developmental Biology
  • Odontology

Background:

  • Root development involves complex biological mechanisms.
  • Most research utilizes rodent models, raising questions about human applicability.
  • Understanding these processes is crucial for regenerative dentistry.

Purpose of the Study:

  • To review recent studies on biological mechanisms in root development.
  • To compare root odontoblast differentiation with coronal odontoblast differentiation.
  • To discuss cementum formation and the role of the epithelial root sheath.

Main Methods:

  • Literature review of recent studies on root development.
  • Comparative analysis of rodent and potential human models.
  • Examination of morphological and phenotypic differences in differentiation and formation processes.

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Main Results:

  • Significant species differences exist between rodents and humans in root development.
  • Root odontoblast differentiation exhibits distinct morphological and phenotypic characteristics compared to coronal odontoblasts.
  • The epithelial root sheath plays a key inductive role in both root development and cementum formation.

Conclusions:

  • Rodent data requires careful extrapolation to human root development.
  • The epithelial root sheath's influence on cementum formation warrants further investigation.
  • Apoptosis and epithelium-mesenchymal transition are potential mechanisms governing the fate of the epithelial root sheath.