Related Experiment Videos
Transdermal application of steroid hormones for contraception
1Medical and Clinical Development Department, CIBA-GEIGY Ltd, Basle, Switzerland.
Summary
Transdermal delivery systems (TDS) show promise for contraception by suppressing ovulation through skin absorption of steroids like estradiol and progestins. Further development is needed for optimal efficacy and tolerability.
Area of Science:
- Reproductive Endocrinology
- Dermatology
- Drug Delivery Systems
Background:
- Transdermal delivery (TD) is established for hormone replacement therapy.
- The application of TD for contraception is a recent development.
- Skin penetration of steroids is feasible with appropriate solvents.
Purpose of the Study:
- To investigate the feasibility of using transdermal delivery systems (TDS) for contraceptive purposes.
- To assess the efficacy of transdermal steroids in suppressing ovulation.
- To explore the potential advantages of TDS for contraception.
Main Methods:
- Utilized reservoir-type and matrix dispersion-type transdermal delivery systems (TDS).
- Administered estradiol (E2) combined with progestins (levonorgestrel or ST 1435) via TDS.
- Monitored ovulation suppression in women using these systems.
Main Results:
- Transdermal delivery systems (TDS) delivering estradiol and levonorgestrel suppressed ovulation.
- Another progestin, ST 1435, also demonstrated ovulation suppression via transdermal absorption.
- Preliminary data indicate the feasibility of transdermal steroid absorption for ovulation control.
Conclusions:
- Transdermal steroid absorption is a viable strategy for ovulation suppression and potential contraception.
- Further development of TDS for contraception is warranted, focusing on adhesion, tolerability, and efficacy.
- The potential benefits of transdermal contraceptive systems justify continued research and development.