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The cellular retinoic acid binding proteins

M Donovan1, B Olofsson, A L Gustafson

  • 1Ludwig Institute for Cancer Research, Stockholm Branch, Sweden.

The Journal of Steroid Biochemistry and Molecular Biology
|June 1, 1995
PubMed
Summary
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Cellular retinoic acid binding proteins (CRABP I and CRABP II) are crucial for retinoic acid transport during development. Gene targeting revealed neither protein is essential for embryonic or adult life.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cellular Biology

Background:

  • Cellular retinoic acid binding proteins (CRABP I and CRABP II) are conserved cytosolic lipid binding proteins.
  • Both proteins are expressed during embryogenesis, particularly in the developing nervous system, craniofacial region, and limb bud.
  • CRABP I is found in adult tissues, while CRABP II is primarily in the skin.

Purpose of the Study:

  • To investigate the roles of CRABP I and CRABP II in retinoic acid transport and metabolism.
  • To understand the subcellular localization and potential regulatory functions of CRABP I.
  • To determine the necessity of CRABPs for embryonic and adult development.

Main Methods:

  • Gene targeting experiments were employed to assess the function of CRABPs.

Related Experiment Videos

  • Subcellular localization studies examined the distribution of CRABP I within cells.
  • Analysis of retinoic acid transport and metabolism pathways.

    • Main Results:

    • Gene targeting revealed that neither CRABP I nor CRABP II is essential for normal embryonic development or adult life.
    • CRABP I exhibits differential cytoplasmic and/or nuclear localization, suggesting a role in intracellular transport.
    • Evidence indicates a potential protein-mediated mechanism controlling nuclear uptake of retinoic acid.

    Conclusions:

    • CRABPs likely regulate retinoic acid transport and metabolism, despite not being essential for survival.
    • CRABP I's localization suggests a role in modulating retinoic acid availability for nuclear receptors.
    • Understanding CRABP function may illuminate mechanisms controlling retinoic acid signaling pathways.