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Related Experiment Videos

Intensive chemotherapy with stem cell support-experience in pediatric solid tumours

C R Pinkerton1

  • 1Royal Marsden NHS Trust, Sutton, Surrey, UK.

Bulletin Du Cancer
|January 1, 1995
PubMed
Summary

High-dose therapy with stem cell rescue shows limited proven benefit in childhood cancers, except possibly for metastatic neuroblastoma. Further randomized trials are needed to clarify its role in specific high-risk pediatric malignancies.

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Area of Science:

  • Pediatric Oncology
  • Hematology
  • Cancer Treatment

Background:

  • High-dose therapy with stem cell rescue (HDT-SCR) has been explored for various childhood solid tumors.
  • A 2006 Consensus Conference reviewed the evidence for HDT-SCR in pediatric malignancies.

Purpose of the Study:

  • To review the current role and evidence for HDT-SCR in childhood cancers.
  • To identify specific pediatric malignancies where HDT-SCR might offer a benefit.

Main Methods:

  • Review of a Consensus Conference findings.
  • Analysis of existing randomized studies and clinical trial data for various pediatric tumors.

Main Results:

  • HDT-SCR has no proven role in most childhood tumors, with the exception of metastatic neuroblastoma.

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  • Evidence for HDT-SCR in rhabdomyosarcoma and Ewing's sarcoma remains inconclusive, though potential benefits in specific high-risk groups are suggested.
  • Promising but unproven roles exist for primitive neuroectodermal tumors and high-risk relapsed Wilms' tumor; results in gliomas are disappointing.

    • Conclusions:

    • HDT-SCR is not generally recommended for childhood cancers outside of metastatic neuroblastoma.
    • Further international collaboration and randomized trials are urgently needed to define the role and optimize the use of HDT-SCR in specific high-risk pediatric cancer subgroups.
    • The high cost and morbidity of HDT-SCR necessitate careful evaluation of its benefits in carefully selected patient populations.