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Ribozymes: biology, biochemistry, and implications for clinical medicine
M Kiehntopf1, E L Esquivel, M A Brach
1Universitätsklinikum Rudolf Virchow, Berlin, Germany.
Journal of Molecular Medicine (Berlin, Germany)
|February 1, 1995
Abstract:
Ribozymes are a class of ribonucleic acid (RNA) molecules that possess enzymatic properties. Upon binding to complementary nucleic acid strands, catalytic degradation takes place via a cleavage reaction. In effect, inactivation of susceptible substrate RNA molecules takes place at a catalytic rate and with a high degree of substrate specificity. This article reviews the biology and biochemistry of this class of molecules and its potential applications in clinical medicine.