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Chromosome 12 abnormalities in malignant ovarian germ cell tumors
E Rodriguez1, J Melamed, V Reuter
1Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Cancer Genetics and Cytogenetics
|July 1, 1995
Abstract:
We analyzed 3 cases of malignant ovarian germ cell tumors (MOGCTs), comprising 1 dysgerminoma and 2 immature teratomas, by banded chromosome analysis and by in situ hybridization (ISH) using a chromosome 12p painting probe. We found evidence of 12p abnormalities in two of them. A possible common genetic pathway of origin of a subset of MOGCTs with testicular germ cell tumors (TGCTs) is discussed.