Related Experiment Video
Updated: Feb 11, 2026

Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
Better visualization of retinoblastoma metastases with Tc-99m sestamibi versus Tl-201
C Aktolun1, H Bayhan, E Ozturk
1Department of Nuclear Medicine, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey.
Abstract:
Tc-99m sestamibi has been shown to accumulate in several primary malignant tumors, but data regarding its use in the detection of distant metastases are limited. Despite its physical limitations, Tl-201 now has a definite place in the routine evaluation of certain primary and metastatic tumors. This report describes the value of Tc-99m sestamibi and its superiority to Tl-201 in the visualization of distant metastases in a 2-year-old girl with bilateral retinoblastoma. Three sites of soft tissue and bone metastasis were demonstrated by Tc-99m sestamibi imaging. Of these metastases, the one in the parieto-occipital region showed evident Tl-201 uptake, while the other two in the right arm and chest wall showed only slightly increased uptake, which could hardly be spotted without the confirmation of a later Tc-99m sestamibi scan. The scintigraphic findings were confirmed with histopathologic examination. Tc-99m sestamibi scan is effective and superior to Tl-201 in the detection of distant soft tissue and bone metastases from retinoblastoma.
Related Concept Videos
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Visual System
Once through the pupil, the light passes through the lens, a...
Visual Agnosia
Photoreceptors and Visual Pathways
Negative Regulator Molecules
Vision

