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[Psychopharmacologic approaches to schizophrenic psychoses]
M Giacardy-Paty1, C Soubrouillard, O Blin
1Laboratoire de Pharmacologie Médicale et Clinique et CPCET, Hôpital de la Timone, Marseille, France.
Abstract:
The dopaminergic hypothesis in schizophrenia has progressively shifted to a bipolar hypothesis. Furthermore, there are numerous interactions between dopaminergic systems and other neurotransmission systems. Therefore, several pharmacological approaches are possible either through the specific antagonism of different dopaminergic receptors subclasses, partial dopaminergic agonists or indirect modulation or through the combined blockade of dopaminergic and serotoninergic, cholinergic or adrenergic receptors. The challenge today is to link a given clinical effect to one specific pharmacological property.